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Came out of the early GHRP-6 optimization work in the 1980s as researchers systematically modified the lead structure looking for improved potency and stability

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Int J Biochem Cell Biol 42:813827 Bhonsle JB, Clark T, Bartolotti L, Hicks RP (2013) A brief overview of antimicrobial peptides containing unnatural amino acids and ligand-based approaches for peptide ligands

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Furthermore, ROS damages membranes and causes cell death by attacking polyunsaturated fatty acids (PUFAs) in lipid membranes, generating high amounts of lipid peroxides